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Histologically, congenital hyperinsulinism can be diffuse, where all beta cells are affected, or focal, where there is a focal area of adenomatosis ( Plasma incretin concentrations in both the fasting and fed state have been measured in patients with different forms of congenital hyperinsulinism

They are also water soluble and therefore lost in the urine, so it is important to receive them daily

Common medications in this class include semaglutide (Ozempic, Wegovy, Rybelsus), dulaglutide (Trulicity), liraglutide (Victoza, Saxenda), and tirzepatide (Mounjaro, Zepbound), though tirzepatide is technically a dual GIP/GLP-1 receptor agonist

If you decide to try the combination approach, start with lower doses of each and gradually increase to assess your tolerance

Cazan D, Mehrmann U, Wenzel A, Maurer JT